Syrian state media said army units pushed deeper into the town near the Lebanese border on Monday, and were fighting street battles with the rebels.
The SANA news agency said that President Bashar al-Assad's troops took control of most of the town of Qusair on Monday.
Opposition activists said at least 52 people were killed on Sunday. At least 13 Hezbollah fighters were also killed, they said.
Al Jazeera's Rula Amin, reporting from Beirut, said: "It seems the government is able to control most of Qusayr ... it has been a rebel stronghold for about one year."
The attack follows a rare interview with the Syrian President Bashar al-Assad released on Saturday, in which he said that his government was not using "fighters from outside of Syria, of other nationalities, and needs no support from any Arab or foreign state".
Our correspondent in Beirut said: "Both sides have sought help from other countries.
"Hezbollah is heavily involved in the fighting, and there are hundreds of foreign fighters in Qusayr. The confrontation has taken a rather regional and sectarian tone. This is about Sunnis fighting Alawites and Shia, not just Syrian rebels fighting government forces."
For weeks, fighting has raged around Qusayr, a town in the central province of Homs that has been under rebel control since early last year.
The intensity of the fighting reflects the importance that both sides attach to the area.
By the government's calculations, Qusayr lies along a strategic land corridor linking Damascus with the Mediterranean coast, the Alawite heartland.
For the rebels, the overwhelmingly Sunni Qusayr has served as a conduit for shipments of weapons and supplies smuggled from Lebanon to opposition fighters inside Syria.
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